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2014-Vol 5-Issue 1

Editorial

MORE REASONS TO RETHINK ABOUT COLAS: THE NOXIOUS FIZZY DRINKS

Have you ever thought what you are drinking, when you go for a carbonated drink? You are gulping down carbon-di-oxide, phosphoric acid, caffeine, fructose/aspartame and minute quantity of an organic diol (ethylene glycol), an ‘antifreeze’ that makes your drinks ‘really chill’, which is also a slow poison. Consider the known facts about the poisonous brew.

Raaz K Maheshwari

Department of Chemistry, SBRM Govt PG College, Nagaur, Rajasthan

Research Articles

EFFECT OF CARBONATES ON SEED GERMINATION AND SEEDLING GROWTH IN PORTULACA OLERACEA L.

One of the most important stresses is alkali stress that effects plants growth and metabolism. The effect of carbonates (NaHCO3, KHCO3 and (NH4)2CO3) on seed germination and seedling growth in Portulaca oleracea L. was investigated. Germination percentage was decrease with increasing concentration of salts.  Root length and dry weight were strongly reduced due to carbonate salts. Shoot length and fresh weight were slightly increased at lower concentration (25mM) of salts and then decreased at higher concentrations (50, 100, and 200mM). From the results, it appears that P. oleracea L. is rather sensitive to carbonate salts during germination and seedling growth.

Patil N. S., Karadge B. A.

Department of Botany, Shivaji University Kolhapur, India

INVESTIGATION OF THE IMPACTS OF CONSTRAINT-BASED ALGORITHMS TO THE QUALITY OF BAYESIAN NETWORK STRUCTURE IN HYBRID ALGORITHMS FOR MEDICAL STUDIES

The subject of how best to present the relationships between the variables under uncertainty was crucial in recent medical studies.  In this study we compared the performance of hybrid structure learning algorithms with using different constraint based methods in skeleton construction phase. We used four different medical Bayesian networks for the comparison. In conclusion, we determined the most powerful combination of learning algorithms as a two phased hybrid method for building the structure.

Emre Dünder, Mehmet Ali Cengiz, Haydar Koç

Samsun Ondokuz Mayıs University Departmen of Statistics, Samsun,Turkey

SCREENING OF ACTINOMYCETES WITH ACTIVITY AGAINST CLINICAL ISOLATES OF GRAM POSITIVE COCCI WITH MULTIRESISTANT PROFILE

Actinomycetes are Gram-positive bacteria widely distributed in the environment and known for the diverse biologically act ive molecules they produce. This study assesses the activity of compounds produced by 40 actinomycete isolates against Enterococcus spp. Staphylococcus aureus and Staphylococcus epidermidis clinical isoalates. The susceptibility profile of the samples was assessed using the agar disk diffusion method. Antimicrobial activity of actinomycetes was evaluated according to the double layer method. Here, two isolates (50 and 8S) exhibited activity against 90% of clinical Staphylococcus spp. and Enterococcus spp. These isolates were grown in starch casein broth at 30˚C for 7 days with constant shaking. After, the culture obtained was filtered to obtain a crude extract, whose antibiotic activity was assessed using the well diffusion technique. In this assay, isolate 50 presented higher activities than that exhibited by isolate 8S. The isolate 50 has been used in different assays looking for production of metabolite optimization.

Themis Collares Antunes, Marcela Proença Borba, Cristina de Castro Spadari, Ana Lúcia Antunes, Ana Paula Guedes Frazzon, José Carlos Germani, Sueli Van Der Sand

Departamento de Microbiologia Imunologia e Parasitologia, Instituto de Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500, 90050-170 Porto Alegre, RS, Brasil.

AN ANATOMICAL INSIGHT ON THE SUPERNUMERARY HEAD OF BICEPS BRACHII AND ITS CLINICAL RELEVANCE – CADAVERIC STUDY

The biceps brachii is as one of the most variable muscle in the human body in terms of number and morphology of its heads. The most frequent variation is the presence of a third head, which has been reported by several authors in different populations.  We studied 80 arms of adult formalin fixed cadavers in the Department of Anatomy, B.L.D.E University’s Sri B M Patil Medical College & research centre Bijapur India. The presence of, number of additional heads and their details of attachments were studied. We observed presence of supernumerary heads of biceps brachii in 3 (3.75%) cases, in which one was having unilateral three heads (1.25%) In another case we encountered bilateral incidence (2.50%). Knowledge of occurrence of supernumerary third head of Biceps brachii muscle may become significant for the orthopedic surgeons, traumatologists, plastic surgeons, radiologist, and physiotherapists.

Ishwar B. Bagoji, Gavishiddappa A. Hadimani, Balappa M. Bannur, B. G. Patil, Ambadasu Bharata, M. A. Doshi, B S Patil

Dept. of Anatomy, Sri B M Patil Medical College, BLDE University Bijapur, Karnataka, India

DESIGN, SYNTHESIS AND PHARMACOLOGICAL SCREENING OF 2-(2-(BENZO [D] OXAZOL-2-YL) PHENYLAMINO)-N-(SUBSTITUTED PHENYL) ACETAMIDES AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS

The endeavor of this study was to design, synthesize and investigate the in vivo anti-inflammatory and analgesic activity of some novel 2-(2-(benzo[d]oxazol-2-yl) phenylamino)-N-(substituted phenyl) acetamide (2A-2F) derivatives. 2-(2-aminophenyl) benzoxazole (D1) was synthesized by the condensation of anthranilic acid with starting material 2-aminophenol in the existence of poly phosphoric acid. A separate route was followed to obtain substituted chloroacetanilides (A1-A6) by the reaction of substituted anilines with chloroacetyl chloride. Finally title compounds were obtained by fusion of 2-(2-aminophenyl) benzoxazole (D1) and substituted chloroacetanilides (A1-A6). The newly synthesized compounds were characterized by IR, NMR and Mass spectral data. The title compounds were evaluated for in vivo anti-inflammatory and analgesic activities by carrageenan induced paw edema and acetic acid induced writhing method respectively. A few of the synthesized compounds manifest promising activity when compared to standard drug diclofenac sodium.

Priyanka, Manish Kumar Gautam, Neeraj Kant Sharma, Keshari Kishore Jha, M. Vijayakumar

Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Bagarpur, Moradabad, India

Short Communications

PHARAMACOGNOSTICAL EVALUATION OF ANTIDESMA ACIDUM RETZ. LEAF: A WILD EDIBLE PLANT

A wild edible plant Antidesma acidum Retz. is large shrub belongs to family Euphorbiaceae. The leaves of Antidesma acidum Retz. are used as vegetable in rural area of Western Ghats and used against in dysentery and for appetizer. In present investigation macroscopic and microscopical characters of leaves were studied. The powder behaviour of leaves indicates the presence of starch, alkaloids, xanthoprotein, tannin, cystine and oil etc. The fluorescence analysis and phytochemical test were done.

Poonam Patil*, Varsha Jadhav (Rathod)

Dept. of Botany, Shivaji University, Kolhapur, (M.S.) India

COMPSOPOGON COERULEUS (BALBIS) MONTAGNE, FRESH WATER RHODOPHYCEAN TAXA FROM HOOGHLY DISTRICT, WEST BENGAL, INDIA

The present paper was communicated with taxonomic description of Compsopogon coeruleus (Balbis) Montagne, a fresh water Rhodophycean member with original citation, phenology, habitat, distribution pattern, ecological note, threats and significance for the first time from Hooghly district, West Bengal, India.

Halder N., Sinha S.N.

Department of Botany, Raja Peary Mohan College, Uttarpara, Hooghly, W.B., India

STANDARDIZATION OF A POLYHERBAL FORMULATION: DIA-CARE

After post general agreement on tariffs and trade (GATT) era there is big surge in Herbal based medicines to find out their potential for treatment and cure of diseases and ailments which can or cannot be cured by well established allopathic formulations. Most of the traditional systems of medicine are effective but they lack of standardization. So there is need to develop standardization technique. Central council for research in Ayurveda has given preliminary guidelines for the standardization of conventionally used formulations. The present study deals with standardization of Dia-care, known to be effective in diabeters mellitus. One sample was procured from manufacturers and subjected to standardization on the basis of organoleptic properties, physical characteristics, physico-chemical evaluation and was compared using in-house formulation. It was observed that the commercial samples matched exactly with that of in -house preparation after performing the standardization.

K. Somasekhar Reddy, Y. Padmanabha Reddy, N. Devanna

Raghavendra Institute of Pharmaceutical Education & Research(RIPER), Anantapuramu, A.P., India

IODINATION OF PARACETAMOL

Iodoresiniferatoxin (I-RTX) is a strong competitive antagonist of the Transient Receptor Potential Vanilloid 1 (TRPV1) receptor. However, resiniferatoxin itself, as a painkiller substance, is a TRPV1 receptor agonist. As paracetamol has also a painkiller action of low intensity, its iodination can have a reverse effect.

Ech-chahad Abdellah, Bouyazza Lahboub*, Giovanni Appendino

University Sidi Mohamed Ben Abdellah Fes National Institute of Medicinal and Aromatic Plants (Morroco) 2Hassan1 University. FST Settat (Morroco)


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