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2011-Vol 2-Issue 2

Review Articles

MANAGEMENT OF IRRITABLE BOWEL SYNDROME

Irritable bowel syndrome is a sign multipart of mysterious cause of disease distinguished with the duodenal ache or else uneasiness connected by means of distressed distortion and frequently inflateing. There are definite drugs which are used for the treatment of irritable bowel syndrome. Anticholenergic as well as spasmolytic mediator is of doubtful advantage for irritable bowel syndrome in spite of optimistic systematic review of deprived eminence testing. Cathartics being recycled for infarction although inadequately manage the irritable bowel syndrome indication intricate. Lopex be finer towards panacea within the development of dysentery however no duodenal ache during irritable bowel syndrome. Zelmac (tegaserod) is a strong- bearable aminoguanidine indole imitative of 5-hydroxytryptamine receptor protagonist, among the properties which speeds up the emptying of the stomach. Mebeverine, a musculotropic antispasmodic agent, may effectively be used in irritable bowel syndrome. Peppermint oil improves the signs of irritable bowel syndrome, together with duodenal ache. Zofran (ondansetron) stops the 5-hydroxytryptamine within the enteric plexuses and thus decreases the cramps of large intestine and movement of food inside the stomach.

Maha Imtiaz, M. Imran Qadir*

College of Pharmacy, Government College University, Faisalabad, Pakistan

POTENT HERBAL HEPATOPROTECTIVE DRUGS- A REVIEW

Hepatic disease (Liver disease) is a term for a collection of conditions, diseases, and infections that affect the cells, tissues, structures, or functions of the liver. Liver has a wide range of functions, including detoxification, protein synthesis, and production of biochemical necessary for digestion and synthesis as well as breakdown of small and complex molecules, many of which are necessary for normal vital functions. There are no specific allopathic medicines uses as hepatoprotective, although different research works are going on some drug. Herbal drugs are more widely used than allopathic drugs as hepatoprotectives because of them are inexpensive, better cultural acceptability, better compatibility, with the human body and minimal side effects. In the current review, it had been tried to redefine the use of important herbal hepatoprotective drugs like Andrographis paniculata; Swertia Chirata etc. that consist of specific chemical constituents who have their specific hepatoprotective activity against hepatotoxicant like ethanol, drugs, chemicals and others. These herbal drugs have shown the ability to maintain the normal functional statues of the liver with or without fewer side effects. These are the reason that’s why herbal hepatoprotectives are mostly preferred by medical practitioners, as well as over- the-counter.

Akhil Bhardwaj, Pankaj Khatri, M.L. Soni, D.J. Ali

Department of Pharma-Biotechnology, Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, Rajasthan, India

SYNTHETIC AND BIOLOGICAL MULTIPLICITY OF ISATIN: A REVIEW

Isatin (2,3-dioxindole) is an endogenous compound identified in humans, and its effect has been studied in a variety of systems. Isatin nucleus having both the keto and lactam moiety has aroused tremendous curiosity due to its diverse biological and pharmacological studies. From literature survey it is well known that isatin heterocycles exhibit manifold importance in the field of medicinal chemistry as a potent chemotherapeutic agent. Biological properties of isatin include a range of actions in the brain and offer protection against certain types of infections. This review represents some synthesized isatin derivatives and their pharmacological profiles which may contribute in future to synthesize various analogs and to develop new pharmacologically less toxic medicines.

 

Manju Pal, Neeraj K. Sharma, Priyanka, K.K.Jha

College of Pharmacy, Teerthankar Mahaveer University, Moradabad, U.P., India

Research Articles

PHYTOPHARMACOGNOSTIC INVESTIGATION OF BAUHINIA TOMENTOSA LINN

The current study reveals about the pharmacognostic characteristics of the roots of Bauhinia tomentosa Linn. (Family: Fabaceae). The following study measures different physical and chemical characters, which are useful in the microscopical as well as microscopical study of the root of the plant.

Shiv Kumar Gupta

Department of Pharmaceutical Sciences Shree Ganpati Institute of Technology NH-24, Ghaziabad, U.P., India

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF SOME NEW HYPOPHOSPHOROUS ADDUCTS OF ACID HYDRAZONES DERIVED FROM 2, 5-DICHLOROANILIDOACETOHYDRAZIDE

A new series of hypophosphorous adducts of acid hydrazones have been synthesized by the reaction of 2, 5-dichloroanilidoaceto hydrazide with various Carbonyl Compounds in 42% to 69% yield. Newly synthesized compounds have been tested for their anti-bacterial activity against gram positive bacteria S.albus, S.aureus and gram negative bacteria E.coli and Pseudomonas piosineus. The compound 1, 4, 11, 12, 13 and 15 shown significant activities and compounds 2, 3, 7, 8 and 9 have shown moderate activity. The same compounds were tested for their anti-fungal activity against Candida albicans, Aspergillus niger and Alternaria alternata at concentration of 30 mg/ml using Savored dextrose agar media. The compound 3, 12, 14, 15 shown significant activities and compound 1, 2, 4, 10, 16 and 17 have shown moderate activity against Candida albicans and Aspergillus niger. All the other compounds did not show significant activity against the fungi at the concentration used.

Raj Narayan Sharma, K P Sharma, S N Dikshit

1Department of Chemistry, NRI College of Engineering and Management, M.P., India

DENSITY AND VISCOSITY STUDIES OF PARACETAMOL IN ETHANOL + WATER SYSTEM AT 301.5 K

Density and Viscosity of drug Paracetamol (PAM) in various aqueous mixtures of ethanol have been determined. These results are further extended for solutes like electrolyte NaCl and non-electrolyte sucrose in the presence of this drug. The density and viscosity data have been analyzed for the evaluation of partial molar volume, molar excess volume, excess viscosity and A & B viscosity coefficients using Jones-Dole equation.

It can be inferred from these studies that this drug acts as a structure-making compound due to hydrophobic hydration of drug molecules. B-coefficients values are found to be positive thereby showing drug solvent interactions. Furthermore these results are correlated to understand the solution behavior of drug.

Muktar Shaikh, Mohd Shafiq, Mazahar Farooqui

Department of Chemistry, Shri Anand college, Pathardi, Dist-Ahmednagar

ADSORPTION OF CATIONIC DYES FROM AQUEOUS SOLUTIONS USING POLYANILINE CONDUCTING POLYMER AS A NOVEL ADSORBENT

In this research, polyanilline (PANi) as coated film onto sawdust was used for removal of methylene blue (as a typical cationic or basic dye) from aqueous solutions. The experiments were conducted using both batch and column systems. The operating variables studied were initial solution pH, adsorbent mass, initial dye concentration and contact time. The experimental data were analyzed by the Langmuir and Freundlich models of adsorption. In order to find out the possibility of reuse, desorption study was also carried out in this investigation. It was found that the currently introduced adsorbents can be used to remove cationic dyes such as methylene blue from aqueous solutions very efficiently. Regeneration of the column or desorption of the dye uploaded adsorbent can also be achieved using very simple and cost effective method with high performance.

 

Reza Ansari, Zahra Mosayebzadeh, Mohammad Banimahd keivani, Ali Mohammad-khah

Chemistry Department, Faculty of science, University of Guilan, Rasht, Iran


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