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PREPARATION & EVALUATION OF β-CYCLODEXTRINS INCLUSION COMPLEXES OF LORNOXICAM FOR SOLUBILITY ENHANCEMENT

Abstract

Lornoxicam is an Anti-Inflammatory Drug which has been widely used but is poorly water soluble. Thus, in the present, an attempt was made to enhance the water solubility by complexation with methyl-β-cyclodextrin to modify the physicochemical properties of Lornoxicam (LX) for solubility enhancement. Among these various Lornoxicam with β-CD inclusion complexes, K5 (1:5) formulations prepared by kneading method shows faster dissolution rate. The concept of formulating Fast Dissolving tablets of LX- β-CD inclusion complex using Effervescent agent i.e. Sodium bicarbonate, Citric Acid offers a suitable and practical approach of faster disintegration and dissolution characteristics. All formulations were evaluated for weight variation, thickness, hardness, friability, drug content uniformity, percent swelling index, in vitro dissolution study, their release kinetics and stability study. Drug and polymers were subjected to compatibility study using FT-IR spectroscopy, which suggests that, there was no interaction between drug and polymers and concluded that the drug, polymers and excipients were compatible to each other. From the in-vitro dissolution studies, a direct relationship of concentration of effervescent agent with drug release was found. F6 showed optimized release with 99.5% drug release at the end of 30 min, i.e. Immediate Release pattern. Further optimized formulation was subjected to stability testing for 2 months at Room temperature and 45ºC/75RH.


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