Fast dissolving tablets (FDTs) are novel types of tablets that disintegrate or disperse in saliva within few seconds without water. Paracetamol was used as a model drug in this formulation. Paracetamol is widely prescribed antipyretic and analgesic drug for all age groups. All the formulations were prepared using direct compression method, which is a conventional method of preparation. Various parameters like pre &post-compressional parameters were tested and final formula was selected based on in-vitro dispersion time and in-vitro dissolution profile. Where, all the formulations were dispersed < 40 seconds and F6 formulation was showing 100% release at 25 minute and faster, compared to the marketed formulation and the formulation was found to be stable.
Journal of Advanced Scientific Research
Bulet Kumar Gupta*, Anuj Moral, Sultan Ahmed, Md. Asraf, Aman Sharma
Department of Pharmaceutics, Kalka Institute for Research & Advanced Studies, Partapur By-Pass Meerut NH-58 (U.P.), India