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SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-SUBSTITUTED HYDRAZINO-6-FLUORO-1, 3-BENZOTHIAZOLES AS ANTI-INFLAMMATORY AGENTS

Abstract

Benzothiazole moiety is expanding its pharmaceutical importance and has been studied frequently for the exploration of pharmacological assistance in varied pharmacological circumstances. In the present investigation a series of 2-substituted hydrazino-6-fluoro-1,3-benzothiazole derivatives was synthesized via the synthesis of 2-hydrazino-6-fluorobenzothiazole and subsequent condensation with substituted acetophenones. The synthesized compounds were evaluated for their possible anti-inflammatory activity. The structures of few representative compounds were elucidated by IR and NMR. For the present work efficacy of compounds was determined by carageenan induced paw oedema method which was comparable with that of Indomethacin (10mg/kg/ml). The results of the study demonstrated moderate to good inhibitory impact of the synthesized compounds on induced inflammation.


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