Fabrication and Replication of Unstructured and Prestructured Magnetorheological ElastomerPURIFICATION AND PHARMACEUTICAL APPLICATION OF BIOACTIVE NATURAL PRODUCT OF SEAWEED TREATED AGAINST MICROBIAL PATHOGENS

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Saravanan K
Durairaj K
Somaprabha A

Abstract

Seaweeds are considered a source of bioactive compounds as they are able to produce a variety of metabolites with the
broad spectrum of biological activities. The phytochemical analysis was performed to confirm the presence of
phytochemical constituents and, carbohydrate, saponin, flavonoids, alkaloid, terpenoid, quinone and phenols were found
positive. Antimicrobial activity was green seaweed was tested against clinical pathogens. A maximum inhibitory activity
was recorded for Escherichia coli with the zone of inhibition 21mm in diameter. Besides the seaweed extracts was found
to inhibit Shigella flexneri. The antifungal activity was tested against the selected pathogens; Pencillium sp, Aspergillus niger,
Aspergillus flavus, Aspergillus sp and Odium caricae. The seaweed extract showed maximum activity against Aspergillus sp with
zone on 41mm. The haemolytic activity of the extracted seaweed revealed a complete absence of haemolytic effect in
blood agar plates. Functional groups modification was carried out with FTIR. The presence of aromatic compounds
appeared in the seaweed extract such as, aromatic α, β, unsaturated aldehyde, amines, nitro compounds and amino
groups were prominently seen. Wound healing studies in mice was carried out for 8 days between control and
experimental treated mice. The seaweed extracts was found effective in wound closure which appeared to be complete
during 8th day. A drastic difference between control and experimental treated mice was noted. Molecular analysis
patterning to protein profile by SDS-PAGE in burn wound healed mice was observed for 8 days.

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How to Cite
K, S., K, D., & A, S. (2021). Fabrication and Replication of Unstructured and Prestructured Magnetorheological ElastomerPURIFICATION AND PHARMACEUTICAL APPLICATION OF BIOACTIVE NATURAL PRODUCT OF SEAWEED TREATED AGAINST MICROBIAL PATHOGENS . Journal of Advanced Scientific Research, 12(02 Suppl 1), 282-289. https://doi.org/10.55218/JASR.s12021122sup112
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Research Article