FORMULATION AND EVALUATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS) OF COMMIPHORA WIGHTTI EXTRACT

Abstract

Commiphora mukul widely known as Guggul herb is highly used by the rural and tribal people for curing various disorders. Natural remedies are more acceptable in the belief that they are safer with fewer side effects than the synthetic ones. Herbal formulations have growing demand in the world market. In the present study an attempt was made to formulate and develop self emulsifying drug delivery system (SEDDS) of methanolic extract of Commiphora wightti (guggul) and to enhance its solubility, dissolution and its bioavailability. The solubility of guggul extract was determined in various oil, surfactant and co-surfactants. Pseudoternary Phase diagram were used for optimization of microemulsion formulation. The prepared formulations of SEDDS were evaluated based on their in-vitro drug release profile, globule size, zeta potential and self emulsifying assessment. In vitro release studies of optimized formulation F3 revealed that release profiles of SEDDS of guggul extract was best expressed by Higuchi equation, as the plots showed highest linearity (coefficient of determination, R2=0.993). It was observed that the optimized SEDDS formulation F3 showed 98.14 % release at 60 min.