https://sciensage.info/index.php/JASR <p><strong>Journal of Advanced Scientific Research (ISSN: 0976-9595) is a peer-reviewed online journal, published&nbsp;Monthly. This Journal publishes original research work, reviews, and short communications that contributes significantly to further the scientific knowledge in the subject areas of Chemistry, Pharmaceutical Research, Biochemistry, Microbiology, Biotechnology,&nbsp; Medicine and applied Biosciences to all the destinations for faster connectivity to respective research, taking due care of speed and pace of knowledge generation .</strong></p> Sciensage en-US Journal of Advanced Scientific Research 0976-9595 https://sciensage.info/index.php/JASR/article/view/2628 <p>Background and Aim: Cervical cancer remains a major public health concern, although timely screening can substantially reduce morbidity<br>and mortality. Conventional pap smear (CPS) is widely used for cervical screening, while liquid-based cytology (LBC) offers technical advantages<br>in specimen preparation and cellular visualisation. This study compared the cytomorphological findings and specimen quality obtained by the<br>two techniques.<br>Materials and Methods: We conducted a prospective observational comparative study over one year at a tertiary care hospital in Northeast<br>India. A total of 160 women attending the gynaecology and cervical screening services were included. Both CPS and LBC evaluated cervical<br>samples from each participant. The preparations were assessed for specimen adequacy, background clarity, benign cytological changes and<br>epithelial abnormalities according to the Bethesda System.<br>Results: Most participants belonged to the 31 to 40-year age group (32.5%), followed by 41–50 years (30.0%). Vaginal discharge was the<br>most frequent clinical complaint (37.5%). LBC demonstrated better specimen adequacy, with satisfactory preparations in 98.1% compared<br>with 93.1% for CPS. LBC more frequently showed a clean background (86.9%) than CPS (67.5%), whereas CPS more often showed blood<br>obscuration. LBC identified ASC-US and LSIL more frequently, while both techniques detected squamous cell carcinoma equally, as observed<br>cytological frequencies.<br>Conclusion: LBC provided better specimen adequacy and background clarity and facilitated recognition of several cytological abnormalities<br>and infective changes. CPS remains a practical and economical screening method, while LBC may be advantageous where appropriate laboratory<br>infrastructure is available.</p> Shreyoshi Dhar Chayanika Saha Sumana Ghosh ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-sa/4.0 2026-09-05 2026-09-05 17 09 01 06 10.55218//JASR.2026170901