https://sciensage.info/index.php/JASR <p><strong>Journal of Advanced Scientific Research (ISSN: 0976-9595) is a peer-reviewed online journal, published&nbsp;Monthly. This Journal publishes original research work, reviews, and short communications that contributes significantly to further the scientific knowledge in the subject areas of Chemistry, Pharmaceutical Research, Biochemistry, Microbiology, Biotechnology,&nbsp; Medicine and applied Biosciences to all the destinations for faster connectivity to respective research, taking due care of speed and pace of knowledge generation .</strong></p> Sciensage en-US Journal of Advanced Scientific Research 0976-9595 https://sciensage.info/index.php/JASR/article/view/2636 <p>Moringa oleifera leaves are nutrient-dense and rich in phenolics, flavonoids and glucosinolate-derived isothiocyanates, yet their bitter, grassy<br>character limits acceptance as a dietary supplement. Gummies, a chewable and palatable dosage form, offer a route to deliver moringa to children,<br>adolescents and adults who avoid tablets or capsules. This review examines how moringa leaf powder and extract have been incorporated into<br>gummy-type formulations, how formulation variables have been optimised, and what health evidence supports the intended benefits. Published<br>formulation studies indicate that gelling-agent type and concentration are the dominant determinants of texture, swelling, syneresis and dissolution<br>time. In a leaf-powder system, 10% gelatin and 1.5% pectin gave the most satisfactory physical characteristics, whereas sucrose and propylene<br>glycol concentrations modulated elasticity and firmness in extract-based gummies. Factorial and response-surface designs are the most suitable<br>optimisation tools, but only simple factorial and completely randomised designs have been reported so far. Evidence for antioxidant, glycaemic,<br>lipid-lowering and anti-inflammatory effects derives mainly from in vitro and animal work, with a few small human studies using leaf powder;<br>to our knowledge, no clinical trial of a moringa gummy has been reported. Safety data at dietary doses are reassuring, but standardisation of leaf<br>material, retention of bioactives in the finished gummy, sugar content and stability remain unresolved. A quality-by-design framework linking<br>material attributes, process parameters and quality attributes is proposed, together with priorities for clinical evaluation.</p> Ashish D Ghatage Vedant A Bandgar Deepak V Sawant Avadhut A More Prasad P Patil Prathamesh D Patil Abhinandan R. Patil Chandraprabhu Jangme ##submission.copyrightStatement## 2026-10-21 2026-10-21 17 10 01 05