STUDY OF IN-VITRO ANTI-INFLAMMATORY ACTIVITY OF ROOT EXTRACT OFPARKINSONIA ACULEATE (LINN).

Abstract

Medicinal plants are of great importance in treating many ailments and diseases traditionally. Parkinsonia aculeate plant is
used to treat many diseased conditions. Parkinsonia aculeate (Linn) is plant from Fabaceae family. Leaves and stem bark
shows anti-inflammatory activity but there is no reported study on the anti-inflammatory activity of the root extract of
Parkinsonia aculeate. In the present study the in-vitro anti-inflammatory activity of pet ether extract, chloroform extract,
ethyl acetate extract, ethanol extract and aqueous extract of Parkinsonia aculeate (LINN) roots were evaluated. The
activity is evaluated using the in-vitro protein denaturation inhibition bioassay and trypsinase inhibitory activity. The
denaturation of protein is induced by heat. The anti-inflammatory activity is found to be significant in ethyl acetate
extract compared to the other extracts. Ethyl acetate extract shows 71.12 % of inhibition to protein denaturation at
100μg/ml concentration compared to the standard diclofenac sodium and shows 75.40 % of inhibition to trypsinase at
100μg/ml concentration compared to the standard diclofenac sodium.