SYNTHESIS, CHARACTERIZATION, MOLECULAR DOCKING STUDY OF GRAPHENE OXIDE CATALYZED NOVEL SCHIFF BASE AND THEIR ANTIMICROBIAL ACTIVITIES

Abstract

A straight forward and greener protocol has been disclosed for the synthesis of 2-(benzlidene)-1-(3-chloropyridin-2-yl) hydrazine derivatives via three component reaction of 3-chloro-2-hydrazinopyridine with substituted benzaldehyde andgraphene oxide by using very convenient reaction conditions. The synthesized compounds have been characterized by FT-IR, 1HNMR, 13CNMR and LCMS. The molecular docking studies of synthesized compounds were conducted and found the possible information between synthesized compounds and DNA gyrase enzyme. Compounds (3a-e) have shown stronger inhibition of DNA gyrase compared to chlorobiocin. These compounds have shown reasonably good antibacterial and antifungal activities compared to the standard drugs Griseofulvin and Cefixime.