PROTECTIVE EFFECT OF PROANTHOCYNIDINS FROM M. NAGI BARK (PMN) ON RESERPINEINDUCED OROFACIAL DYSKINESIA IN EXPERIMENTAL ANIMALS

Abstract

Reserpine-induced neurodegeneration and free radical damage causing orofacial dyskinesia is an animal model for Parkinsonism. Aim of work was to assess neuroprotective and in-vivo free radical scavenging activity of proanthocynidins isolated from bark of Myrica nagi (PMN). In the existing study, vacuous chewing movements (VCM) and orofacial bursts (OB) in Wistar rats were induced by subcutaneous administration of reserpine (1 mgkg-1 ) on day 1, 3 and 5. Effect of PMN on VCM, OB and in-vivo antioxidant defence enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GSH), extent of lipid peroxidation (LPO) and dopamine was studied in forebrain region. PMN significantly reversed reserpine induced VCM, OD. PMN treatment significantly elevated levels of SOD, CAT, GSH and inhibited LPO. PMN also restored levels of dopamine in forebrain region indicating potential role of PMN is reversal of reserpine induced neurodegeneration and Parkinson’s disease.