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Neurofibromatosis (NF) is a rare genetic disease which causes tumors to grow on the nerve tissues. These being noncancerous and less life threatening, patients affected with NF can lead a normal life if the cosmetic issues are ignored. Although there are treatments available like surgeries or use of FDA approved drugs that can control the progression and symptoms in people affected with this disorder, researchers are still trying to find a potent solution that can permanently curb this disease. Novel technologies such as stem cell technology and CRISPR genome editing are being studied that could act as a cheaper, reliable, noncomplex and less time-consuming solution to this rare condition. In the current scenario, COVID-19 affected NF patients have neither shown progression of the NF condition or any severe side effects after being administered with vaccines. This review gives a gist of the drugs which are currently in use for treatment of this disease and various signaling pathways involved in the activation of Neurofibromatosis that could be inhibited using computational methods in the near future so as to obtain a solution which can be employed in the early stages itself.
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