Eco-friendly HPLC Strategies for Pharmaceutical Analysis

Abstract

The pharmaceutical business has a significant challenge in the worldwide need to adapt processes to green analytical chemistry (GAC) standards.One of the most common procedures employed at different points in the pharmaceutical manufacturing process is high-performance liquidchromatography (HPLC), which results in massive amounts of organic hazardous waste. Therefore, it is important to incorporate GAC conceptsinto pharmaceutical research and analysis. Although there has been a rise in recent years in the number of papers detailing green chromatographytechniques, they have not yet been widely adopted by the pharmaceutical industry. Reasons for this include analysts’ doubts about whetheror not they have met the method’s requirements, a lack of time to make the necessary adaptations to their standard HPLC instruments, anda lack of relevant experience. This chapter provides a high-level review of green strategies for liquid chromatography (LC) that can be simplyapplied to common instruments for creating environmentally friendly HPLC approaches in pharmaceutical analysis. The goal is to motivatethe analytical community within the pharmaceutical sector business to not only develop new green methods but also to transition the wellestablishedtraditional HPLC methods into environmentally green sustainable alternatives.