NOVEL SCHIFF BASE METAL (II) COMPLEXES WITH AZIDE AS COLIGANDS: A STUDY ON ANTIMICROBIAL, LARVICIDAL AND ANTIOXIDANT ACTIVITIES

Abstract

Schiff bases are considered as promising biologically active ligand which is attained from carbonyl compounds and primary amines. It is also prepared from amino acids which are essential for living metabolism. The interactions of transition metal ions with biologically active ligands provide most fascinating area in Coordination chemistry. Schiff base metal complexes are highly significant because of their functions in various fields such as medical, industrial and agricultural. The present study deals with the synthesis of a new series of azido based transition complexes derived from o-vanillin and L-valine. The complexes were structurally characterized by spectroscopic techniques such as FTIR and UV-Vis., The FTIR spectra confirmed the tridentate coordination nature of the Schiff base via imine nitrogen, phenolic oxygen and one of the oxygen atom of carboxylate group. Radical scavenging activity was carried out by CUPRAC, FRAP, DPPH and H2O2 methods. Mosquito larvicidal and ovicidal activities against Culex quinquefasciatus larvae over 24 h exposure time period were performed for the synthesized compounds. Further, LC50 and LC90 values were calculated. In order to explore the bioactivity profile, the synthesized compounds were screened against four different species of bacteria and fungi. The synthesized copper complexes exhibit significant results in all these studies.