SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SUBSTITUTED N2-((1R, 4R)-4-AMINOCYCLOHEXYL)-N6-(PHENYL)-9-CYCLOPENTYL-9H-PURIN-2,6-DIAMINE DERIVATIVES

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DOI : https://doi.org/10.55218/JASR.s2202112330
Published Oct 31, 2021

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Dhanraj Kamble
Department of Chemistry, S.B.E.S. College of Science, Aurangabad, Maharashtra, India
Anil Shankarwar
Department of Chemistry, S.B.E.S. College of Science, Aurangabad, Maharashtra, India
Radhakrishna Tigote
Department of Chemistry Dr. B. A. M. University Sub campus, Osmanabad, Maharashtra, India
Yuvaraj Sarnikar
Department of Chemistry Dayanand Science College, Latur, Dist. Latur, Maharashtra, India
Mubarak Shaikh
Department of Chemistry, Radhabai kale Mahila Mahavidyalaya, Ahemadnagar, Maharashtra, India
Pravin Chavan
Doshi Vakil Arts College and G.C.U.B. Science 8 Commerce College, Goregaon-Raigad, Maharashtra, India
Balaji Madje
Department of Chemistry Vasantrao Naik Mahavidyalaya, Aurangabad, Maharashtra, India

Abstract

In this study, we have synthesized N2-((1r,4r)-4-aminocyclohexyl)-N6-(substitutedphenyl)-9-cyclopentyl-9H-purin-2,6- diamine derivatives (7a-j) from N-(-substituted phenyl)-9-cyclopentyl-2-fluoro-9H-purin-6-amine, and cyclohexane-1,4 diamine under microwave irradiation condition and examined for their antibacterial activity against Escherichia coli, Streptococcus aureus and Bacillus subtilis strains. All compounds (7a-j) displayed moderate to good antibacterial activity in Minimum Inhibition Concentration (MIC).

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How to Cite
Kamble, D., Shankarwar, A., Tigote, R., Sarnikar, Y., Shaikh, M., Chavan, P., & Madje, B. (2021). SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF SUBSTITUTED N2-((1R, 4R)-4-AMINOCYCLOHEXYL)-N6-(PHENYL)-9-CYCLOPENTYL-9H-PURIN-2,6-DIAMINE DERIVATIVES. Journal of Advanced Scientific Research, 12(03 Suppl 2), 265-269. https://doi.org/10.55218/JASR.s2202112330
Issue
Vol 12 No 03 Suppl 2 (2021): Journal of Advanced Scientific Research
Section
Research Articles
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