DEVELOPMENT AND EVALUATION OF FLOATING MICROSPHERES OF ANTICONVULSANT DRUG BY 32 FULL FACTORIAL DESIGN

Abstract

Aim of the present study was to develop and evaluate gastroretentive carbamazepine microspheres by solvent evaporation technique. From the preliminary study, the batch FMC2 was selected for factorial study. Factorial batches showed the mean particle size (FFMC1- FFMC9) in the range of 245.32±0.21 to 405.14±0.14μm. The percentage yields were found to be in the range from 72.09±0.21 to 96.83±0.23. The buoyancy percentage was calculated and found that all formulations were able to float on dissolution medium for 12 h. The swelling study was found to be 799.0±0.14 to 876.4±1.67. Batch FFMC2 showed better drug release i.e. 99.25%. The optimized formulation FFMC2 showed n value of 0.8601 and R2 value of 0.9984 respectively. The optimized formulation obeys Korsmeyer-Peppas release. SEM images of microspheres were spherical, discrete, and freely flowing. ANOVA for the formulations showed P-value less than 0.0500. The stability study indicated no significant change in the microspheres. In radiographic images floating microspheres were retained in stomach of rabbit for 12 hours.