SKIN PERMEATION STUDY OF NANOMIEMGEL FOR ANTIFUNGAL ACTIVITY OF EXTRACT SAMADERA INDICA

Abstract

The transdermal route of drugs has received increased attention in recent years due to numerous advantages over the oral and injectable routes, such as avoidance of the hepatic metabolism, protection of drugs from the gastrointestinal tract, sustained drug delivery, and good patient compliance. The assessment of ex vivo permeation during the pharmaceutical development process helps in understanding the product quality and performance of a transdermal delivery system. Generally, excised human skin relevant to the application site or animal skin is recommended for ex vivo permeation studies. However, the limited availability of the human skin and ethical issues surrounding the use of animal skin rendered these models less attractive in the permeation study. The aim of this study to determine the skin permeation of Nanomiemgel for using antifungal plant extract by using rat abdominal skin was conducted through Franz diffusion cell. The ex vivo skin permeation studies were performed using Franz diffusion cell with rat skin as permeation membrane. Significant increase in permeability parameters was observed in nanomiemgel formulations (P less than 0.05). This research discussed the alternative skin models that have been used for skin permeation. Ex vivo permeation studies of rat were performed for each animal and trail, five parameters are to be collected. After removal of patch on completion of a week, each of the areas was examined for any sign of erythema or edema.