SKIN CARCINOGENESIS, MOUSE MODELS AND ANTICANCER ACTIVITY OF PLANT EXTRACTS: AN OVERVIEW

Abstract

Plants have been used by man as a cost-effective remedy to cure various diseases since ancient times. Plant kingdom has
been continuously screened by researchers around the world for the formulation of herbal drugs to treat life-threatening
diseases including cancer. Plant bioactive metabolites are of much importance in novel drug discovery to combat cancer
and saving human lives. This review paper focuses on the studies done earlier for evaluating anticancer activity of plants
using different in vitro and in vivo methods. The causes of skin carcinogenesis and mouse models used in preclinical
studies for cancer drug development are the other highlights of this paper. Plenty of researches have been conducted in
last some years throughout the world which reveal that plants do possess a wide variety of compounds having anticancer
properties. Therefore, this review is an attempt to draw attention towards some important researches carried out in last
some years which may be helpful in further researches for effective anticancer drug development in future.