PHYTOCHEMICAL ANALYSIS OF METHANOLIC LEAVES EXTRACT OF GREWIA FLAVESCENS AND THEIR BIOLOGICAL ACTIVITY

Abstract

Tannins, the non-nutritive substances from plant sources exhibit potent biological activities that lower the risk of chronic diseases without any side effects. Tannins are most abundant and multipotent molecules exhibiting antioxidant, antiinflammatory and anti gastritis activity and thus being effective in the treatment of degenerative diseases. The study aims to prove the biological activities of tannins that target several key events involved in the development of diseases. Partially purified tannins from the methanolic extract of Grewia flavescens was subjected in vitro studies to note the antioxidant activity, Phospholipase A2 inhibition and K+\H+ ATPase inhibition respectively, while the free radical scavenging activity was noted by its 1, 1-diphenyl 2-picrylhydrazyl (DPPH) radical scavenging activity with the EC50 value of 2.72μg/mL. Anti inflammatory activity is by the inhibition of PLA2activity with IC50 value of 23.52 μg/mL and ant gastritis activity is by inhibiting K+\H+ ATPase activity with an IC50 value of 30.16μg/mL, which is marginally closer to omeprezole, the standard drug with an IC50 value of 27.62μg/mL. Wide group of natural multipotent molecules like tannins with manifold chemo preventive activities represent a promising class.