THE STUDY OF PHYSICO-CHEMICAL PROPERTIES OF TRANSITION METAL COMPLEX OF METOLAZONE AND AS POTENTIAL THERAPEUTIC AGENT BY ANALYTICAL METHODS

Abstract

It has been observed that biologically active compounds become more effective as well as bacterio-static upon chelation with metal ions1. The many drugs have shown their biological properties with metal-complex ions, hence they are used in the field of Pharmacology6. Due to this pharmaceutical action of such ‘drug complexes’ are hence studied. In the present work, drugs are used as ligands or chelating agents that contain atoms or groups like N, O, P, S etc that can attach with metals or ions by coordinate bond formation with complexes. Although a large number of therapeutic agents are known, the literature survey shows that very rare work has been done on the metal complexes of diuretic drugs. Due to this the synthesis of metal complexes derived from diuretic drugs and their physio-chemical analysis carried out ligandmetal ratio of these complexes in solution in the present work. The complexes of Cu salts are prepared. By using Job’s method, the stability constant of the complex was observed and molar conductance was taken. The experiment has been carried out by using the conductometry and pH-metry. To confirm metal-ligand ratio, conductometric titrations were carried out at room temperature. By using analytical grade metal salts titrations were carried out with “systronics conductivity-meter” using conductivity cell having cell constant 1 at room temperature.