NOVEL SUBSTITUTED-3H-[1,2,3]TRIAZOLO-[2,3-b]QUINOLINES AS POTENT ANTIMICROBIAL AGENTS

Abstract

Novel series of methyl and phenyl substituted-3H-[1,2,3]triazolo-[2,3-b]quinolines are synthesized by reacting 2-chloro4-methyl/4-phenyl-quinoline with sodium azide under appropriate reaction conditions which in turn obtained by the chloro substitution of 2-hydroxy-4-methyl/phenyl substituted quinolines. The hitherto synthesised compounds are characterized by IR, NMR and Mass spectroscopy. In-vitro screening of the synthesized compounds against microbes (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Asperigillus niger and Candida Albicans) revealed that these scaffolds can act as efficient antimicrobials.