EVALUATION OF THE ANTI-ULCER ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF HUGONIA MYSTAX

Abstract

The present study was designed to evaluate the antiulcer activity of ethanol extract of leaves of Hugonia mystax (HMEE) in pylorus ligation, ethanol and indomethacin induced models in rats HMEE was prepared and subjected to acute toxicity study as per CPCSEA guideline no. 420. Two doses i.e. 200 mg/kg and 400 mg/kg were selected for the further study. In pylorus ligation induced ulcer model, the parameters taken for assessing the anti-ulcer activity were gastric volume, pH, free acidity, total acidity and ulcer index. Ulcer index was also determined in ethanol and indomethacin induced ulcer models. Pretreatment with the extract has shown dose dependent decrease in ulcer index in all the experimental models of ulcers (indomethacin, ethanol and pylorus ligation induced ulcers) and also reduced the total acidity, free acidity, gastric volume and increased the pH in pylorus induced ulcer model. However, the results of gastric volume and pH were not significant with 200mg/kg dose. It is concluded from this study that HMEE possess antiulcer properties in different gastric ulcer models. The antiulcer activity of the HMEE may be attributed to the polyphenolic compounds that are present in it.