STUDY ON EFFECT OF VITAMIN-C AS ADD ON THERAPY WITH ANTIDIABETIC DRUGS IN NEWLY DIAGNOSED TYPE-2 DIABETES MELLITUS PATIENTS

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, usually associated with oxidative stress. Beside hyperglycemia, oxidative stress also plays a major role in diabetes and its complications such as diabetic neuropathy, nephropathy and retinopathy. Reduction of oxidative stress may have better outcome in diabetic patients. Therefore the present research was designed to study the effect of oral hypoglycemic agents (OHA) and vitamin-C on oxidative stress and lipid profile along with glycemic control. A total of 94 type-II diabetes mellitus patients were taken in open label, prospective study and divided them in to four groups, Group-A (Glimepiride), Group-B (Glimepiride + Vitamin-C), Group-C (Metformin + Voglibose) and Group-D (Metformin+ Voglibose+ Vitamin-C). Glycemic control, lipid profile and oxidative stress were compared before and after 3 months of treatment in all the 4 groups. Data was analyzed By using SPSS Software. At the end of 3 months, significant glycemic control was found in all 4 groups (p less than 0.001) but only Group-B and Group- D showed significant reduction of oxidative stress (p less than 0.001). Marked lipid control was noticed in Group-B, Group-C and Group- D. Supplementation of vitamin-C along with OHA therapy has additional effect on glycemic control and lipid level and being an antioxidant, Vitamin-C reduces the oxidative stress in diabetes mellitus patients.