EFFECT OF NATURAL POLYMER ON RELEASE RETARDING RATE OF GLIMEPIRIDE SUSTAINED RELEASE TABLET

Abstract

ABSTRACT Glimepiride is a primary III generation drug belonging to the class of sulphonylurea which shows the hypoglycaemic effect and is a very potent drug with a prolonged duration of action. It is given in doses of 1-8 mg once a day. The prime objective of this work was to formulate a sustained release matrix anti-diabetic tablet by using a natural polymer guar gum. Using this natural polymer, sustained release tablets of glimepiride were formulated by using wet granulation technique in various trials with the change in the concentration of polymers. The formulated granules were evaluated for pre-compression parameters like bulk density, tapped density, angle of repose, Hausner’s ratio and compressibility ratio. The tablets were also evaluated for post-compression parameters like in-vitro swelling studies, uniformity weight, drug content hardness, friability, in-vitro dissolution study and kinetic data analysis. The results obtained indicated that the formulated tablets results are within the range. In comparison with all the formulations, it was observed that F2 showed optimum release for 12 hours in sufficiently sustained manner. The kinetic data analysis also proved that it followed the zero-order release and fitted in the Higuchi model with an r2 value of 0.994.