FORMULATION DEVELOPMENT AND EVALUATION OF MAMENTINE HCL LOADED THERMO SENSITIVE IN SITU NANOGEL FOR NASAL DELIVERY

Abstract

The object of present study was to formulate and evaluate mamentine HCl loaded thermo sensitive in situ nanogel for nasal delivery. In present project a novel drug delivery system i.e. in situ polymeric gel was designed in the manner that the gel load mamentine HCl in better concentration and it also incorporates penetration enhancer as a way to enhance the absorption of release drug from gel to the systemic circulation. In this research work Different Nanoparticles were (NP) prepared, using ionotropic gelation method with slight medication in which chitosan (0.4 % w/v) was dissolved in aqueous acetic acid solutions (1 % v/v) (pH 6.1), while TPP (0.1 % w/v) was dissolved in deionized water. Then the dried nanoparticle incorporated with in situ gel. In situ was gel was prepared by cold method using the solutions of Poloxamer-188 and Carbopol-934. From this study, it is concluded that, among all formulations prepared, MG8 was the best optimized formulation. Prepared gel can be used as promising nasal drug delivery system for the anti -Alzheimer drug Mamentine HCl, which enhance nasal residence time owing to increased viscosity and mucoadhesive characteristics; furthermore, it also exhibited a permeation enhancing effect.