IN VITRO CYTOTOXIC POTENTIAL OF HALOPHILIC BLACK YEAST- AUREOBASIDIUM PULLULANS AGAINST HUMAN BREAST CARCINOMA CELL LINES

Abstract

Solar saltern serves as a hotspot for many hidden microorganisms, where the fungal community seems to be a most unexploited one. Halophilic fungi represent a wide source of yet undiscovered compounds, besides its unprecedented chemical structures, often possess interesting biological activities. This work was designed to study the synthesis of bioactive metabolites from halophilic fungi isolated from Vedaranyam saltpans. Altogether, five halophilic strains with two black yeasts like fungi were observed from the soil sample. Among, crude extracts of halophilic black yeast Aureobasidium pullulans exhibited the superlative response to MCF-7 cell lines at the concentration of 300µg/ml with an IC50 of 174.29 µg/ml respectively. Witnessing these remarkable preliminary findings, provoking to identify the drug motifs and chemical characteristics nature.