ELUCIDATION OF KINETIC AND THERMODYNAMIC PARAMETERS OF THE REACTIVITY OF THE HALOGENATION REACTIONS OF REGIO ISOMERS OF METHYL INDOLE IN AQ

Abstract

The study assesses the relative reactivity of the regio isomers of methyl indole in bromination reactions on a quantitative scaffold. The kinetic and thermodynamic data have been obtained for the bromination reactions with the regio isomers of methyl indole by N-Bromo succinimide in the aqueous medium using hydrodynamic voltammetry technique. These reactions follow second order kinetics and are found to be very rapid and the rapidity of the reactions compels the use of the special technique employed herein. The variation in reaction rates with temperature was studied. The specific reaction rates, energies of activation, entropy change and the pre-exponential factor in the reactions were evaluated. The specific reaction rates at 306 K for 1-methyl indole, 2-methyl indole and 3-methyl indole are 2800, 4955 and 1558 M -1m sbn -1 respectively. The data has been analyzed to quantitatively ascertain the steric constraints in the dynamics of these reactions.