Comparison of the Antiepileptic Activity of Commiphora Molmol Leaves by Different Methods

Abstract

The objective of this study was to evaluate the antiepileptic activity of the leaves of Commiphora molmol in animal models. Acute toxicity studies were performed in rats after administration of the extract orally in graded doses. Antiepileptic activity was evaluated by using Maximum electroshock-induced convulsion and Pentylenetetrazole-induced convulsion at 250 mg/kg and 500 mg/kg dose. The phytochemical study of plant revealed the presence of carbohydrate, flavonoids, saponins and alkaloids and suggests that plant had antiepileptic property. The 500mg/kg dose showed more antiepileptic property than 250 mg/ kg of C. molmol. The present study concludes that leaf extract of Commiphora molmol showed more antiepileptic activity by Pentylenetetrazole-induced convulsion method in compared to Maximum electroshock-induced convulsion method.