FORMULATION AND CHARACTERIZATION OF MICROEMULSION OF POORLY WATER SOLUBLE DRUG GLYBURIDE
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Abstract
The objective of the present investigation was to develop and evaluate microemulsifying drug delivery system for
improving the delivery of a BCS class II antidiabetic agent, glyburide (GLY). The solubility of glyburide in oils,
surfactants and co-surfactants (Capmul MCM: Tween80: Span20) was evaluated to identify the components of the
microemulsion. Pseudoternary phase diagrams diagram was utilized to identify the optimal excipient composition to
formulate the microemulsion system and the area of microemulsion existence. Glyburide microemulsion was
characterized by refractive index, optical clarity, assay, dye solubility, viscosity, surface tension, pH, drug content,
polydispersity index, drug loading, entrapment efficiency, particle size, zeta Potential, scanning electron microscopy
(SEM), differential scanning calorimetry measurements (DSC) and viscosity. The in vitro dissolution profile of glyburide
microemulsion was evaluated the pure drug in pH 7.4 buffers. The chemical stability of glyburide in microemulsion was
determined as per the International Council for Harmonisation (ICH) guidelines.
improving the delivery of a BCS class II antidiabetic agent, glyburide (GLY). The solubility of glyburide in oils,
surfactants and co-surfactants (Capmul MCM: Tween80: Span20) was evaluated to identify the components of the
microemulsion. Pseudoternary phase diagrams diagram was utilized to identify the optimal excipient composition to
formulate the microemulsion system and the area of microemulsion existence. Glyburide microemulsion was
characterized by refractive index, optical clarity, assay, dye solubility, viscosity, surface tension, pH, drug content,
polydispersity index, drug loading, entrapment efficiency, particle size, zeta Potential, scanning electron microscopy
(SEM), differential scanning calorimetry measurements (DSC) and viscosity. The in vitro dissolution profile of glyburide
microemulsion was evaluated the pure drug in pH 7.4 buffers. The chemical stability of glyburide in microemulsion was
determined as per the International Council for Harmonisation (ICH) guidelines.
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How to Cite
Vishvakarma, P., Saravanan, K., & Sharma, S. (2021). FORMULATION AND CHARACTERIZATION OF MICROEMULSION OF POORLY WATER SOLUBLE DRUG GLYBURIDE. Journal of Advanced Scientific Research, 12(02 Suppl 1), 270-281. https://doi.org/10.55218/JASR.s12021122sup111
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Research Article
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