EVALUATION AND BIOLOGICAL ROLE OF SCHIFF BASE METAL COMPLEXES

Abstract

The versatile nature of the lanthanide Schiff base complexes, make them an important candidate in catalysis of numerous
organic transformations like oxidation of amines to their corresponding oxygen containing derivatives. Schiff bases and
their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl
compounds and widely used for industrial purposes and also exhibit a broad range of biological activities including
antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties.
Development of a new chemotherapeutic Schiff bases and their metal complexes is now attracting the attention of
medicinal chemists. A novel Schiff base ligand was synthesized by aldehyde with Aromatic Amine to form Schiff base
ligand. It is mixed with 1st Row transition metal ions to form metal complexes. Complexes are characterized by
Elemental analysis, UV- spectroscopy, Infrared spectroscopy and NMR. Elemental analysis of the metal complexes
suggested that the stoichiometry ratio is 1:2 (metal-ligand). The UV-spectrum gives clear idea about the metal
complexes. The Schiff base complexes have been screened for their invitro antibacterial activity against three bacteria via;
(Staphylococcus sp, Pseudomonas sp, Bacillus sp.) and also studied antifungal activities (Aspergillus sp and Aspergillus sp).
Similarly, anti-oxidant studiesof metal complexes were also performed.