TARGETING TRPV1 SIGNALING PATHWAY THROUGH NATURAL PRODUCTS ININFLAMMATORY CANCER

Abstract

TRPV1 (Transient potential vanilloid 1) receptor or the vanilloid (capsaicin) receptor, is a heat-activated non-selective cationic channel which gets affected by inflammation causing mediators and hence leads to acute and chronic pain. It is present on sensory nerves and need activation by specific stimuli like bacterial endotoxins, osmostic stress, pH, ROS, temperature to cause initiation and modulation in inflammation and pain. Another major implication of TRPV1 is its use in cancer therapy. Being activated by compounds like capsaicin, it shows different mode of action in different models. Anti-nociceptive effect of capsaicin is well known whereas its anticarcinogenic activity involves an increase in intracellular Ca2+ signaling leading to apoptosis of targeted oncogenic cells. Capsaicin is not the only phytoconstituent which activates TRPV1 channel, but a bunch of other compounds like piperine, cannabidiol, eugenol, ginsenosides also show their TRPV1 based activity. This review mainly focused on such natural products which show both antiinflammatory as well as anti-carcinogenic activity, in order to recommend their use in inflammatory cancer. It also summarises some other compounds as well which show their action on TRPV1 either analgesic or anti-inflammaotry and proposed their study in chemotherapy.