DETERMINATION OF ANTI-ARTHRITIC ACTIVITY OF NYCTANTHES ABORTRISTIS FLOWER EXTRACT USING COMPLETE FREUND’S ADJUVANT (CFA)-INDUCED ARTHRITIS MODEL

Abstract

Nyctanthes abortristis belongs to the family Oleaceae having various medicinal values. Different parts of plants such as stem, bark, leaves and flowers have been reported already for their pharmacological properties. The present study is focused on the anti-arthritic potential of Nyctanthes abortristis flowers extracted from different solvents. Qualitative and uantitative estimation of isolated compounds and antioxidant activity has been studied using various antioxidant assays. Methanolic extract was used to determine the anti-arthritic activity in Complete Freund’s adjuvant (CFA) induced arthritis rats by oral administration of crude extract at 200mg/kg and 400mg/kg dose concentrations. Paw volume analysis and haematological parameter were analysed on 28th day of treatment. The results exhibited significant antiarthritic activity for N. abortristis flower extract.