PHYSICOCHEMICAL ASSESSMENT OF AgNPs INVIGORATED ANTIDERMATOPHYTIC CREAM FROM LEAVES OF CRESCENTIA CUJETE L. - A NANOPHARMACEUTICAL PLOY

Abstract

To combat pathogens, a wide variety of antibiotics has been developed and sold commercially through time. The proliferation of pathogenic microorganisms poses a threat to public health. However, a more serious proble m arises when these pathogens develop resistance against commercial antibiotics. The research on screening and development of drugs for their activity is therefore, an unending process and there is hope of finding out anti-dermatophytic drugs from indigenous plants. In this study, the leaf extract of Crescentia cujete L. was employed as a green reducing agent to synthesise highly-stable antidermatophytic cream using invigorated C. cujete silver nanoparticles. Incorporation of nanosized particles in cosmetic formulations can improve the stability of active constituents like vitamins, unsaturated fatty acids and antioxidants, thereby enhancing their therapeutic value. Specifically, metallic nanoparticles have attracted attention due to their application in the medical field as well as cosmetics, food, paint, and textile industry. The assessment involves physicochemical attributes that include grittiness, pH, rheological property, emulsion and stability tests.