FORMULATION AND CHARACTERIZATION OF POLYHERBAL TOPICAL CREAM

Abstract

Herbal plants and their combination report therapeutic as well synergistic effect that has been recognized in medicine. So, taking into account this factor, polyherbal topical cream formulation was prepared by using plant extracts, to improve patient compliance, enhance antimicrobial spectrum and enhance aesthetic properties. The objective of this study was to formulate and evaluate topical polyherbal cream for the delivery of the active constituents present in plants to improve skin diseases. The plant extracts of Ocimum sanctum (OS), Rubia cordifolia (RC) and Glycyrrhiza glabra (GG) were utilized for the preparation of cream. The formulated cream was subjected to different evaluation parameters and the results depicted that the spreadability of the formulation was low (17.80±1.10g. cm/sec) and this low value ofspreadability coefficient was sufficient suggesting easy spreading and no signs of grittiness. In rheological studies, all the cream formulations also exhibited the same non-Newtonian behavior. Polyherbal topical cream showed potential antimicrobial activity against all selected microorganisms. Polyherbal topical cream (PHC5) was ideal in terms of viscosity than other formulations and showed good drug release. Thus, the formulated polyherbal cream was found to be stable in terms of all physicochemical properties.