EVALUATION OF ANTI-UROLITHIATIC ACTIVITY OF POLYHERBAL FORMULATION BY USING IN-VIVO MODEL

Abstract

The present study was aimed to evaluate the anti-urolithiatic activity of polyherbal formulation (i.e. Lithout Tablets) by using in-vivo model. For the preparation of polyherbal formulation i.e., Lithout tablets, Wet granulation method was used and the in-vivo anti-urolithiatic activity was evaluated by ethylene glycol induced urolithiasis in rat model. The results of the formulation complies the IPQC tests and the results of in-vivo anti-urolithiatic activity are determined by ANOVA followed by Dunnett’s test. From the present study, it can be concluded that animals treated with standard (Cystone) drug and Lithout tablet in dose of 200 mg/kg of body weight exerted significant anti-urolithiatic activity and protection against tubular interstitial damage in kidneys and liver in ethylene glycol induced urolithiatic rats.