SCREENING FOR ANALGESIC AND ANTI INFLAMMATORY ACTIVITIES OF ETHANOLIC EXTRACT OF JUSTICIA GENDARUSSA BURM LEAVES

Abstract

Ethanol extract of the leaves of Justicia gendarussa Burm was subjected to analgesic and anti-inflammatory activities in animal models. Albino Wistar rats and mice were the experimental animals respectively. Different CNS depressant
paradigms like analgesic (determined via Eddy's hot plate approach and acetic acid writhing approach) and antiinflammatory activity (determined via carrageenan induced paw edema using plethysmometer in albino rats) were carried
out, following the intra-peritoneal administration of ethanol extract of formulation Justicia gendarussa Burm leaves (EEJG)
at the dose level of 250mg/kg and 500mg/kg. The analgesic and anti-inflammatory activities of ethanol extracts of EEJG
showed significant results (P andlt. The maximum analgesic activity was observed at 120 min at the dose of
500mg/kg (i.p.) and analgesic and anti-inflammatory activity was compared with standard drug Diclofenac sodium (5
mg/kg). Ethanol extract of Justicia gendarussa Burm leaves has shown significant analgesic and anti-inflammatory activities
at the dose of 500mg/kg and was comparable with corresponding standard drugs. The activity was attributed to the
presence of phytoconstituents in the tested extract.