AN OVERVIEW ON HYDROXYCHLOROQUINE AND COVID -19

Abstract

Recently, a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), emerged in China. Despite drastic containment measures, the spread of this virus is ongoing. SARS-CoV-2 is the
aetiological agent of coronavirus disease 2019 (COVID-19) characterized by pulmonary infection in humans. Preliminary
trials of chloroquine repurposing in the treatment of COVID-19 in China have been encouraging, leading to several new
trials. Here we discuss the possible mechanisms of chloroquine interference with the SARS-CoV-2 replication cycle.
There is a long trail of research studies testing the in vitro and in vivo efficacy of chloroquine and its derivatives in
treating and preventing infection by various coronavirus species. More recent findings have highlighted the possibility of
treating patients infected with the 2019 novel coronavirus, SARS-CoV-2. This review describes About COVID-19 and
Hydroxychloroquine and mechanism of action of chloroquine, and summarizes the available literature highlighting the
efficacy of chloroquine as an anti-coronavirus agent.