CEPHALOSPORIN PRODUCTION WITH FREE 8 IMMOBILIZED CEPHALOSPORIUM ACREMONIUM CELLS 8 DETERMINATION OF OXYGEN TRANSFER RATE IN STIRRED TANK REACTOR
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Abstract
Cephalosporin production by free and agar immobilized Cephalosporium acremonium cells was investigated in a stirred tank
reactor. Cephalosporin production was increased two times with immobilized cells. In order to verify the oxygen
transfer efficiency in STR, oxygen mass transfer coefficient was determined by using dynamic gassing out method at the
end of steady state operation of the reactor after achieving cephalosporin production. The oxygen mass transfer
coefficient (KL
a) obtained in STR with 20 % (V/V) agar immobilized beads, at 1 VVM (Unit volume of air per unit
volume of the reactor per minute) of air flow rate and 250 RPM of agitator speed gave maximum amount of antibiotic
production in the reactor. The oxygen mass transfer coefficient (KL
a) obtained in stirred tank reactor (STR) is 21hr-1.
reactor. Cephalosporin production was increased two times with immobilized cells. In order to verify the oxygen
transfer efficiency in STR, oxygen mass transfer coefficient was determined by using dynamic gassing out method at the
end of steady state operation of the reactor after achieving cephalosporin production. The oxygen mass transfer
coefficient (KL
a) obtained in STR with 20 % (V/V) agar immobilized beads, at 1 VVM (Unit volume of air per unit
volume of the reactor per minute) of air flow rate and 250 RPM of agitator speed gave maximum amount of antibiotic
production in the reactor. The oxygen mass transfer coefficient (KL
a) obtained in stirred tank reactor (STR) is 21hr-1.
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How to Cite
Rani, A., & Kumar, A. (2020). CEPHALOSPORIN PRODUCTION WITH FREE 8 IMMOBILIZED CEPHALOSPORIUM ACREMONIUM CELLS 8 DETERMINATION OF OXYGEN TRANSFER RATE IN STIRRED TANK REACTOR. Journal of Advanced Scientific Research, 11(Suppl 6), 138-143. https://doi.org/16
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Research Article
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