IN SILICO STRUCTURAL, FUNCTIONAL AND PHYLOGENETIC ANALYSIS OF PNEUMONIA VIRUS SURFACE GLYCOPROTEIN FROM A SEAFOOD MARKET OF CHINA

Abstract

Severe acute respiratory syndrome (SARS) caused by SARS related coronaviruses (SARSr-CoVs) has a great diversity in
forming the zoonotic epidemic diseases in different countries of the World. Some viruses from sea food market of China
causing pneumonia are associated with the 2019 novel coronavirus in rural areas of the different parts of the country. The
pathogens have the capacity to transmit from person to person. The surface glycoprotein of the viruses plays a key role
for zoonotic infections among the hosts. The glycoprotein helps the virus for adsorption to the host cells and helps disease
development. In silico molecular characteristics and proteomic structure of the said surface glycoprotein from pneumonia
virus was studied in the present research. It was found that the surface glycoprotein of the pneumonia virus was about
141 kDa stable leucine rich acidic proteins. Phylogenetic analysis of the protein indicated the similarity with spike
glycoprotein of bat coronavirus. Attempts were made to describe the physicochemical structure and function of the
surface glycoprotein of the virus by the computational analysis of the data collected from different software tools.