IN SILICO INTERACTIONS OF DI-HYDROXY MYRICETIN WITH EZH2 PROTEIN

Abstract

Development of an alternative and complementary method for cancer prevention and treatment can be achieved by discovering effective herbs and elucidating their underlying mechanisms. Myricetin is a naturally occurring flavonol with hydroxyl substitutions at the 3, 5, 7, 3', 4' and 5' positions. We followed simple molecular docking method to screen the interaction between a polycoumb protein EZH2 and dihydroxy myricetin, a flavonol isolated from fruits of Ficus glomerata Roxb.Amino acid sequences Gln 791, Asn 842, and Met 793 of prostate cancer protein interacted with isolated flavonoid dihydroxy myricetin. These interactions support the EZH2 molecule to become a lead drug candidate for combating prostate cancer.