SYNTHESIS AND ANTIBACTERIAL STUDIES OF NEW ANALOGS OF 2-PYRAZOLINE FROM HALOGEN SUBSTITUTED α, β UNSATURATED AROMATIC KETONE

Abstract

Pyrazoline are familiar and important nitrogen containing five member heterocyclic compounds. Halogenated pyrazoline are widely studied for their antimicrobial activities. Present projection associated with a novel series of substituted 2- pyrazoline were prepared by the reaction with halogen substituted α, β unsaturated aromatic ketone i.e chalcones and hydrazine hydrate using alkaline condition. The newly synthesized 2-pyrazolines were characterized according to their physical constant and spectroscopic data. All the novel synthesized compounds were tested by their antibacterial action in vitro disc diffusion method against two gram +ve and two gram -ve bacteria. Synthesized compounds shows moderate to good activity.