SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF ARYLIDENE AND HETEROARYLIDENE OF 2-((4-(5-MERCAPTO-1,3,4-OXADIAZOL-2YL) PHENYL) AMINO) THIAZOL- 4(5H)-ONE DERIVATIVES

Abstract

A new series of amido linked heterocycles arylidine/heteroarylidine were prepared by introducing oxadiazole and
thiazolidine moieties. The respective arylidine derivatives were assessed for their anti microbial activity against four
bacterial strains and three fungal strains. Throughout the synthesis of heterocyclic compounds it was observed that 2-((4-
(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl) amino)thiazol-4(5H)-one was worked as versatile intermediate, this
intermediate was then condensed with various substituted aromatic aldehydes to obtain a novel series of compounds.
Some of those compounds were found potent against the two gram positive, two gram negative and three fungal stains.
The newly synthesized compounds were characterized by most acceptable analytical techniques i.e. IR, Mass, 1H NMR,
13C NMR. Broth dilution method was used to perform anti microbial activity.