SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL SCREENING OF ((12E)-4-METHYL-N-((4- OXO-4H-CHROMONE-3-YL) METHYLENE)-1,2,3,-THIADIAZOLE-5-CARBOXYLIC ACID HYDRAZIDE AND THEIR TRANSITION METAL COMPLEXES

Abstract

A Schiff base (12E)-4-methyl-N-((4-oxo-4H-chromone-3-yl)methylene)-1,2,3,-thiadiazole-5-carboxylic acid hydrazide
was obtained by the condensation of 4-oxo-4H-chromene-3-carbaldehyde and 4–Methyl-1,2,3,-thiadiazole-5-carboxylic
acid hydrazide and the synthesized schiff base was characterized by various analytical technique such as I.R., 1H-NMR,
13C-NMR and Mass spectrometry. Further it was used for the complexation with different transition metal ions such as
Fe (II), Co(II), Ni (II), Cu(II) and Zn (II) by using molar ratio of metal to ligand as 1: 2. The proposed structures of metal
complexes have been studied by I.R, Thermogravimetric analysis and 1H-NMR, spectroscopic techniques. The
synthesized compounds were evaluated for in vitro antimicrobial screening and the results were compared with standard
drugs. The antimicrobial result shows the metal complexes exhibit remarkable antibacterial and antifungal activity as
compared to parent ligand.