RAPID AND GREENER ULTRASOUND ASSISTED SYNTHESIS OF SERIES (2-((SUBSTITUTED 2- CHLOROQUINOLIN-3-YL) METHYLENE)-3,4-DIHYDRONAPHTHALEN-1(2H)-ONE) DERIVATIVES AND THEIR BIOLOGICAL ACTIVITY

Abstract

In the current research framework, an efficient and greener synthesis has been developed. A new series of α, β
unsaturated carbonyl compounds have been designed by the reaction between 3,4-dihydronaphthalen-1(2H)-one with
various substituted quinolines in presence of NaOH as a base, EtOH:Water (1:1) act as a greener solvent under
conventional and ultrasound irradiation methods. From the comparison between conventional and ultrasound-assisted
synthesis, it was observed that the ultrasound assisted method provided 63-83% yield in 30-45 min against 75-90 min
required getting 46-57% yield by conventional method. The newly synthesized derivatives were characterized by the
most acceptable analytical techniques i.e. IR, 1H NMR, 13CNMR and Mass spectral analysis, also were evaluated for their
in-vitro anti-microbial activity against two gram positive, two gram negative and three fungal strains.