DEVELOPMENT AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES OF ACECLOFENAC BY MICROEMULSION TECHNIQUE USING LECITHIN, PLEURONIC F-68, AND SODIUM GLYCOCHOLATE

Abstract

The present study aimed to enhance the solubility of poorly soluble drug aceclofenac using nanonization technique. Solid-lipid nanoparticles of aceclofenac were prepared by the microemulsion technique. The organic phase contained the drug, lecithin, lipid, and the aqueous phase contained pleuronic F-68 and sodium glycocholate in varying concentrations. The formulations were optimized based on stirring rates, stirring time and ultrasound amplitude, and the number of cycles. Five different formulations were prepared. The formulations were characterized for particle size analysis, zeta potential, in-vitro release studies, and stability analysis. The formulations F1 and F2 were found to be acceptable in the size range and zeta potentials -20 mV indicated their physical stability. The formulation F2 exhibited enhanced dissolution rate and the release profile showed an initial burst release of drug followed by sustained release.