COUMARIN-DIHYDROPYRIMIDINONE HYBRIDS: DESIGN, VIRTUAL SCREENING, SYNTHESIS AND CYTOTOXIC ACTIVITY AGAINST BREAST CANCER

Abstract

Breast cancer is the most invasive form of cancer in women. It is characterized by over production of oestrogens which is
mainly mediated by over-expression of aromatase. In the presented work we have designed a library of fifty coumarindihydropyrimidinone
hybrids and screened them virtually for their aromatase inhibitory potentials through molecular
docking tools. Docking was carried out against human aromatase (PDB Id: 3S7S) using exemestane as standard drug. Six
compounds with best docking scores and interactions were selected and also analysed for in silico drug likeliness and
toxicity. Further these six compounds were synthesized and characterized through spectrometric techniques. Further
these were evaluated for cytotoxic potentials against breast cancer cell lines using MTT assay. Compounds CD8 and
CD28 were found most potent among the all. The synthesized compounds must be explored further for discovery of a
suitable therapeutic candidate against breast cancer.