NORTRACHELOGENIN -AN ACTIVE COMPONENT IN ZINGIBER OFFICINALE AS AN EFFICIENT THROMBOLYTIC AGENT – AN IN SILICO APPROACH

Abstract

Thrombosis is a very serious condition that is often treated with anti-coagulants or blood thinners. Due to the serious
threat that it entails, it is necessary to identify efficient alternatives from natural sources to prevent thrombosis. This
paper discusses one such attempt to study the efficiency of the phytoconstituents in Zingiber officinale for thrombolytic
activity using molecular docking analysis. One of the bioactive compounds in Zingiber officinale namely Nortrachelogenin
was assessed for its drug-likeliness using ADMETSAR server and it was found that the compound was in compliance with
the Lipinski’s rule of five. The binding affinity of Nortrachelogenin with the targets for thrombosis namely Protein
Disulphide Isomerase, Plaminogen Activator Inhibitor-1, Plasmin, Thrombin Activated Fibrinolysis Inhibitor and
thrombin was performed using Autodock following the standard procedure. Clopidogrel, the standard drug for
thrombosis was used as a reference and it was found that Nortrachelogenin has more binding affinity and higher inhibition
for PAL-I, Plasmin and TAFI than the standard drug Clopidogrel. This finding suggests further testing of
Nortrachelogenin as potential thrombolytic agent that will be better than the existing drugs.