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Actinomycetes are virtually unlimited sources of novel compounds with many therapeutic applications and hold a
prominent position due to their diversity and proven ability to produce novel bioactive compounds. The present study is
aimed to prove the antagonistic activity of marine actinomycetes against uropathogens. 13 marine actinomycetes were
isolated from various marine sediment samples collected from different stations in the Azhimala coastal region, part of
the Arabian Sea on the western coast of India. The sample collection and isolation of actinomycetes were done by
following the standard microbiological methods and the isolated colonies were characterized based on their
morphological parameters. The morphologically distinct 13 isolates obtained in the present study, the isolates SD65,
SD66, SD67, SD68, SD69, SD70, SD71, V66, V67, V68, V69,V70,V71 among them 3 isolates,V67,V68 and V70
showed significant antagonism against selected uropathogens collected from a tertiary care center in
Thiruvananthapuram, Kerala. The results were promising and indicated that actinomycetes with distinctive biological
activity are abundant in the marine environment along Kerala's coast.
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