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Due to their potent biological activity, heterocyclic compounds have been used extensively in pharmacological research.
Researchers' interest has been drawn to the heterocyclic molecule thiazine, which has four carbon atoms, one nitrogen
atom, and one sulphur atom. It has interesting pharmacological properties. In the present work, a series of new thiazine
derivatives were synthesized from substituted chalcone derivatives. Starting material was acetophenone derivatives. The
structures of these compounds were confirmed by IR, NMR, Mass and elemental analysis. The synthesized compounds
(IVa-IVe) were screened for anti-tuberculosis activity against Mycobacterium tuberculosis and the results show that some of
these derivatives possess good activity against Mycobacterium tuberculosis.
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