SPHERICAL CRYSTALLIZATION: A TOOL TO IMPROVE SOLUBILITY OF DRUGS

Abstract

Spherical crystallization is a technique in which crystallization and agglomeration are carried out synchronously in one step to form compact spherical form. The most common methods used in spherical agglomeration are quasi emulsion solvent diffusion method, ammonia diffusion system, neutralization technique and co-agglomeration. It succeeded to improve dissolution property of poorly soluble drugs. This can change drug powder properties such as flowability, wettability, packability, compressibility. It has wider applications in improvement of poorly compressible drugs; it has wider application in improvement of compressability of poorly compressible drugs, masking bitter taste of drugs, improving dissolution property, bioavailability and solubility of drugs. Agglomeration crystals converted into tablet forms thus helping us by saving time and reducing cost.